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The size of the penis is decided for men while they
are still embryos floating in the confines of the female
uterus. One may say that the size of the penis can
actually determined even before conception by
forecasting the effects of the combination of genetic
material from the two parents. However, there is no
known reliable method for such forecasting.
At the physical level, the penis size is handled by
the HOX genes. This family of transcription factors play
a key role in body patterning during the embryonic stage
of development. Humans have 39 HOX genes organized in
four clusters and tasked with major roles in the
development of the nervous system, axial skeleton,
external genitalia and limbs. This situation could one
day provide the definitive proof of the existence or
lack of connections between the size of the limbs and
that of the penis. Many people believe that the size of
the penis can be estimated from the size of hands or
feet and the fact that the same genes handle the
formation of both genitalia and limbs could provide the
missing clues.
Mutations in these genes could trigger malformations
to the external genitalia, such as the micropenis (when
the penis is less than half an inch in size) or the
macropenis, which is a penis of abnormally large size.
The size of the penis can also be influenced by the
level of exposure to various hormones of the developing
embryo. One study based on data provided by professor
Alfred Kinsey found that homosexual men have
statistically larger penises than heterosexuals, which
could be explained by exposure to estrogen.